Chrome DevTools: Some preferences are now persisted through to incognito windows
Last updated: April 30, 2015
It's worth going incognito when debugging (since you get a clean slate and no browser extensions).
DevTools will now persist your appearance preferences (docking position, size, pane layout, etc) and devtools settings (disable cache, etc) into the incognito window.
This is helpful as you can now debug JavaScript in an incognito window, and trust your usual DevTools customisations will still be available.
More information in this issue.